Endocrine Abstracts

A 44-year-old gentleman known to have adult polycystic kidney disease with chronic renal failure was found to be profoundly hypothyroid in predialysis assessments in the renal clinic. He was symptomatic feeling tired and generally unwell with multiple problems, which were initially all attributed to his renal failure. Investigations of his thyroid by ultrasound revealed two nodules in the left lobe and one nodule in the right lobe of the thyroid. FNAC failed to differentiate b...

Introduction: Testosterone (T) improves muscle strength in hypogondal men. It is unclear if testosterone has similar effects in prefrail and frail elderly men with low T. We conducted a randomised double-blind placebo-controlled parallel group study to determine the effects of T on muscle mass and strength, physical function and quality of life in prefrail and frail elderly men.Methods: Two hundred and sixty two prefrail and frail elderly men (Fried e...

Introduction: Frailty, a common cause of disability and dependency in the elderly is a multifactorial condition; ageing-associated endocrine dyregulations may play an important role. It is not known if testosterone (T) deficiency contributes to frailty, through its effects on muscle (sarcopenia) and physical function.Objective: To investigate the relationship between T and frailty in elderly men in a cross-sectional observational study in community-dwell...

Background: Testosterone (T) levels decline gradually with increasing age in men. However, age-related decline in several functional domains (e.g. frailty, cognitive deficits, osteoporosis) accelerates in the eighth decade. It is not known if the loss of function in the oldest old is related to a more precipitous fall in T.Objective: To determine if total testosterone (TT) declines more rapidly in men in the eighth compared to those in the sixth and seve...